IHC ESTROGEN,PROGESTERONE & HER-2neu *

Estrogens are secreted by the gonads, adrenal glands and placenta. Total estrogens provide an overall picture of estrogen status for men and women. Progesterone assay is useful for ascertaining whether ovulation occured in a menstrual cycle. It helps to evaluate placental function in pregnancy and maybe used in the workup of patients with Adrenal / Testicular tumors. Her-2 overexpression in breast carcinoma is associated with shorter disease free interval and shorter overall survival. Her-2 positive breast cancers tend to be more aggressive but treatments that target Her-2 are very effective. Expression of Her-2 protein is an indication for specific therapy with Trastuzumab / Herceptin / Pertuzumab / Neratinib in patients with breast cancer.